| Bioactivity | β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects[1]. |
| Name | β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE |
| Formula | C59H92N8O19 |
| Molar Mass | 1217.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang Y, et al. Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment. Bioorg Med Chem Lett. 2023 Oct 15;95:129493. |
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE
CAS: F: C59H92N8O19 W: 1217.40
β-Glucuronide-NB-bis-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antipr
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